Desbois D, Roquebert B, Peytavin G et al. In vitro phenotypic susceptibility of human immunodeficiency virus type 2 clinical isolates to protease inhibitors. Antimicrob Agents Chemother. Pregnant women: AUC 74% lower in pregnant women receiving indinavir without low-dose ritonavir compared with nonpregnant patients. Can Crixivan be taken with other medications? Tashima KT, Horowitz JD, Rosen S "Indinavir nephropathy. Budesonide Topical: CYP3A4 Inhibitors Strong may increase the serum concentration of Budesonide Topical. Management: Per US prescribing information, avoid this combination. Canadian product labeling does not recommend strict avoidance. If combined, monitor for excessive glucocorticoid effects as budesonide exposure may be increased. salbutamol brand names australia salbutamol
The appropriate doses for this combination, with respect to efficacy and safety, have not been established. Preliminary clinical data suggest that the incidence of nephrolithiasis is higher in patients receiving indinavir in combination with ritonavir than those receiving CRIXIVAN 800 mg q8h. Triazolam: Protease Inhibitors may increase the serum concentration of Triazolam. ONGLYZA and placebo respectively. Registered trademark of Pfizer, Inc. Registered trademark of Eli Lilly and Company. Qaqish RB, Fisher E, Rublein J, Wohl DA "HIV-associated lipodystrophy syndrome.
Hypersensitivity: anaphylactoid reactions; urticaria; vasculitis. HIV-infected women not planning a pregnancy may use any available type of contraception, considering possible drug interactions and contraindications of the specific method. In addition, consistent use of condoms is also recommended even during pregnancy to prevent transmission of HIV or other sexually transmitted diseases. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Tell your doctor if your condition persists or worsens.
Indinavir interacts with many drugs. Ribociclib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ribociclib. Management: Avoid use of ribociclib with strong CYP3A4 inhibitors when possible; if combined use cannot be avoided, reduce ribociclib dose to 400 mg once daily. Dasatinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Dasatinib. Management: Use of this combination should be avoided; consider reducing dasatinib dose if a strong CYP3A4 inhibitor must be used. Take this medication by as directed by your doctor. Dosage is based on your medical condition, age, and response to treatment. Your dose may be gradually increased until the drug starts working well. Follow your doctor's instructions closely to reduce the risk of side effects.
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects. Indinavir deposition in synovial fluid may have resulted in monoarthritis in a patient. Simvastatin: CYP3A4 Inhibitors Strong may increase the serum concentration of Simvastatin. PONATinib: CYP3A4 Inhibitors Strong may increase the serum concentration of PONATinib. Crixivan does not cure HIV infection or AIDS and you may continue to experience illnesses associated with HIV-1 infection, including opportunistic infections. You should remain under the care of a doctor when using Crixivan. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Moyle GJ. Resistance to antiretroviral compounds: implications for the clinical management of HIV infection. Immunol Infect Dis. HIV-infected adults. AIDS Clinical Trials Group protocols 150 and 258. Ann Intern Med. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. When taken together, St. John's wort may cause your body to process your HIV medication more quickly. Clinically significant adverse reactions, potentially leading to severe, life-threatening, or fatal events from greater exposures of concomitant medications. Aprepitant: CYP3A4 Inhibitors Strong may increase the serum concentration of Aprepitant. During pregnancy, this medication should be used only when clearly needed. However, it is now normal to prescribe HIV medicines for pregnant women with HIV. This has been shown to decrease the risk of giving HIV to the baby. Indinavir may be part of that treatment. Discuss the risks and benefits with your doctor. No evidence of mutagenicity or genotoxicity was observed in in vitro microbial mutagenesis Ames tests, in vitro alkaline elution assays for DNA breakage, in vitro and in vivo chromosomal aberration studies, and in vitro mammalian cell mutagenesis assays. No treatment-related effects on mating, fertility, or embryo survival were seen in female rats and no treatment-related effects on mating performance were seen in male rats at doses providing systemic exposure comparable to or slightly higher than that with the clinical dose. In addition, no treatment-related effects were observed in fecundity or fertility of untreated females mated to treated males. Both Crixivan and atazanavir are associated with indirect unconjugated hyperbilirubinemia. Combinations of these drugs have not been studied and coadministration of Crixivan and atazanavir is not recommended.
Vinflunine: CYP3A4 Inhibitors Strong may increase the serum concentration of Vinflunine. The clinical significance of these gender differences in the pharmacokinetics of indinavir is not known. Mix to a uniform solution. Label “refrigerate”. Stable for 2 weeks refrigerated. Dispense in tight container as defined in USP. Patient may experience headache, nausea, vomiting, muscle pain, insomnia, sweating a lot, rhinitis, or rhinorrhea. Have patient report immediately to prescriber depression, thrush, cough, flu-like symptoms, or signs of liver problems dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or jaundice HCAHPS. Concomitant use of trazodone and CRIXIVAN may increase plasma concentrations of trazodone. Adverse events of nausea, dizziness, hypotension and syncope have been observed following coadministration of trazodone and ritonavir. If trazodone is used with a CYP3A4 inhibitor such as CRIXIVAN, the combination should be used with caution and a lower dose of trazodone should be considered. American Thoracic Society ATS and Centers for Disease Control and Prevention CDC. Targeted tuberculin testing and treatment of latent tuberculosis infections. Am J Respir Crit Care Med. This drug is used with other to help control infection. It helps to decrease the amount of HIV in your body so your can work better. This lowers your chance of getting HIV complications such as new infections, and improves your quality of life. Anon. New drugs for HIV infection. Med Lett Drugs Ther. Do not share needles or other injection equipment. The cumulative frequency of nephrolithiasis events increases with increasing exposure to Crixivan; however, the risk over time remains relatively constant. NOT be taken with CRIXIVAN. Relative to indinavir 800 mg three times daily alone. Study conducted in HIV-positive subjects. Comparison to historical data on 16 subjects receiving indinavir alone. Pimavanserin: CYP3A4 Inhibitors Strong may increase the serum concentration of Pimavanserin. estrace
Some sedative medications include clonazepam lorazepam zolpidem and others. Gariano RF, Cooney EL. Uveitis following administration of the protease inhibitor indinavir to a patient with AIDS. Clin Inf Dis. Luvox to treat obsessive-compulsive disorder. Deflazacort: CYP3A4 Inhibitors Strong may increase serum concentrations of the active metabolites of Deflazacort. Management: Administer one third of the recommended deflazacort dose when used together with a strong or moderate CYP3A4 inhibitor. Marijuana might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking marijuana along with sedative medications might cause too much sleepiness. Medication Guide for a complete list of ingredients in ONGLYZA. Proc Natl Acad Sci USA. Brinzolamide: CYP3A4 Inhibitors Strong may increase the serum concentration of Brinzolamide. Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Registered trademark of Pfizer, Inc. Brambilla AM, Novati R, Calori G, et al. "Stavudine or indinavir-containing regimens are associated with an increased risk of diabetes mellitus in HIV-infected individuals. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Take indinavir by mouth on an empty stomach at least 1 hour before or 2 hours after eating. You may also take it with a light meal that is low in calories, fat, and protein. Take indinavir with water. You may also take it with other liquids such as skim or nonfat milk, juice, coffee, or tea. Take indinavir with a full glass 8 ounces of water or skim milk. You may also drink juice, coffee, or tea with this medicine. Drink at least 6 glasses of water each day to prevent kidney stones while you are taking indinavir. Use and dose must be determined by your doctor.
Indinavir is metabolized by and inhibits CYP450 3A4 isoenzymes and may potentially interact with many drugs. See for steps to prevent or manage these possible and known significant drug interactions, including dosing recommendations. Consider the potential for drug interactions prior to and during Crixivan therapy; review concomitant medications during Crixivan therapy; and monitor for the adverse reactions associated with the concomitant medications. Adequate hydration recommended for all patients receiving indinavir. Gentle DL, Stoller ML, Jarrett TW, Ward JF, Geib KS, Wood AF "Protease inhibitor-induced urolithiasis. Fetal plasma drug levels 2 hours after dosing were approximately 3% of maternal plasma drug levels. Merrill DP, Moonis M, Chou TC et al. Lamivudine or stavudine in two- and three-drug combinations against human immunodeficiency virus type 1 replication in vitro. J Infect Dis. Talk with your health provider. ONGLYZA or TZD was not permitted during the study. The optimal dosing regimen for use of indinavir in pediatric patients has not been established. For patent information: www. This leaflet provides a summary of information about Crixivan. If you have any questions or concerns about either Crixivan or HIV, talk to your doctor. labetalol mexico
Indinavir MK 639 pharmacokinetic study group. Indinavir MK 639 drug interactions studies. Adequate hydration is recommended. Risk is substantially higher in pediatric patients versus adults. Crixivan is usually prescribed with other anti-HIV drugs such as ZDV also called AZT 3TC, ddI, ddC, or d4T. Crixivan works differently from these other anti-HIV drugs. Talk with your doctor about how you should take Crixivan. How should I take Crixivan? Alfuzosin: Protease Inhibitors may increase the serum concentration of Alfuzosin. Concomitant use of Crixivan and St. John's wort Hypericum perforatum or products containing St. John's wort is not recommended. Coadministration of Crixivan and St. John's wort has been shown to substantially decrease indinavir concentrations see and may lead to loss of virologic response and possible resistance to Crixivan or to the class of protease inhibitors. Lymphadenopathy, spleen disorder, and hemolytic anemia have also been reported but rarely. Increased spontaneous bleeding in hemophiliacs and acute hemolytic anemia have been reported during postmarketing experience. Protease inhibitors may slow down how quickly your liver processes atorvastatin. Cobicistat is also a protease inhibitor. Haas DW, Fessel WJ, Delapenha RA et al. Therapy with efavirenz plus indinavir in patients with extensive prior nucleoside reverse-transcriptase inhibitor experience: a randomized, double-blind, placebo-controlled trial. J Infect Dis. These are not all the possible side effects of ZERIT. Indinavir is an inhibitor of the cytochrome P450 isoform CYP3A4. Refer to the quetiapine prescribing information for recommendations on adverse reaction monitoring. Patients with renal or hepatic impairment should not be given colchicine with CRIXIVAN. Apixaban: CYP3A4 Inhibitors Strong may increase the serum concentration of Apixaban.
Alosetron blocks the action of a chemical called serotonin in the intestines. This slows the movement of stools bowel movements through the intestines. For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. Note: Relapsing infection may require at least 6 weeks of therapy Vannier 2012. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Brexpiprazole: CYP3A4 Inhibitors Strong may increase the serum concentration of Brexpiprazole. Management: Reduce brexpiprazole dose to 50% of usual with a strong CYP3A4 inhibitor; reduce to 25% of usual if used with both a moderate CYP3A4 inhibitor and a CYP2D6 inhibitor, or if a strong CYP3A4 inhibitor is used in a CYP2D6 poor metabolizer. Sildenafil dose should not exceed a maximum of 25 mg in a 48-hour period in patients receiving concomitant CRIXIVAN therapy. Use with increased monitoring for adverse events. Dose reduction of Crixivan to 600 mg every 8 hours should be considered when taking delavirdine 400 mg three times a day. Do not administer with a meal high in calories, fat, and protein. Graves' disease, polymyositis, Guillain-Barré syndrome reported in the setting of immune reconstitution; time to onset is more variable and can occur many months after initiation of antiretroviral therapy. No dosage adjustment is recommended based on gender. Agenerase amprenavir Oral Solution US prescribing information. Bad taste in the mouth; diarrhea; dizziness; drowsiness; headache; mild stomach pain or upset; nausea; tiredness; vomiting; weakness. Kopp JB, Miller KD, Mican JA, et al. "Crystalluria and urinary tract abnormalities associated with indinavir. AUC, C max or trough concentration. cheapest generic xalatan
Hélal A. HIV protease inhibitors and increased bleeding in hemophilia? Spooner KM, Lane HC, Masur H. Guide to major clinical trials of antiretroviral therapy administered to patients infected with human immunodeficiency virus. Clin Infect Dis. How should I take ZERIT? Administration with a substantial meal 48. Crixivan is an oral capsule used for the treatment of HIV Human Immunodeficiency Virus. HIV is the virus that causes AIDS acquired immune deficiency syndrome. Crixivan is a type of HIV drug called a protease PRO-tee-ase inhibitor. How does Crixivan work? When indinavir is taken with delaviridine, levels of indinavir may increase. This may cause pain in your side, blood in your urine, nausea, vomiting, or diarrhea. The dosage is based on your medical condition, response to treatment, laboratory tests, and other you may be taking. Follow your doctor's instructions about any restrictions on food, beverages, or activity. CYP3A4 inhibitor. Monitor for increased mifepristone toxicity regardless of dose or indication. MedroxyPROGESTERone: CYP3A4 Inhibitors Strong may increase the serum concentration of MedroxyPROGESTERone. Major Adverse Cardiac Event MACE.
CRIXIVAN alone vs. zidovudine plus lamivudine. Pharmacokinetics of indinavir appear to be comparable in Caucasians and Blacks based on pharmacokinetic studies including 42 Caucasians 26 HIV-positive and 16 Blacks 4 HIV-positive. Study 028, a double-blind, multicenter, randomized, clinical endpoint trial conducted in Brazil, compared the effects of Crixivan plus zidovudine with those of Crixivan alone or zidovudine alone on the progression to an ADI or death, and on surrogate marker responses. Check with your healthcare provider. Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children. NIH. National Institutes of Health "Guidelines for the use of antiretroviral agents in pediatric HIV infection. vivitrol
Patients with hemophilia: There have been reports of spontaneous bleeding in patients with hemophilia A and B treated with protease inhibitors. In some patients, additional factor VIII was required. In many of the reported cases, treatment with protease inhibitors was continued or restarted. A causal relationship between protease inhibitor therapy and these episodes has not been established. Comparisons included Crixivan plus zidovudine plus lamivudine vs. Crixivan alone vs. zidovudine plus lamivudine. After at least 24 weeks of randomized, double-blind therapy, patients were switched to open-label Crixivan plus lamivudine plus zidovudine. Some medicines may slow down how quickly your liver processes ivabradine. Always have another kind of birth control eg, condoms to use as a backup in case you miss pills. Also, always have an extra, full pack of pills. Refer to the quetiapine prescribing information for initial dosing and titration of quetiapine. Rev Inst Med Trop Sao Paulo. Oral: Must administer with food. Shake suspension gently before use. Once opened, a foil pouch can be emptied on a dosing spoon, in a cup, or directly into the mouth. Prasugrel: CYP3A4 Inhibitors Strong may decrease serum concentrations of the active metabolites of Prasugrel. Whitehouse Station, NJ 08889, USA. Gajewski LK, Grimone AJ, Melbourne KM, Vanscoy GJ "Characterization of rash with indinavir in a national patient cohort.
The recommended dosage of Crixivan is 800 mg usually two 400-mg capsules orally every 8 hours. Alosetron may also be used for purposes not listed in this medication guide. AUC of a single 800 mg oral dose of indinavir and a 36% decrease in indinavir C max. Indinavir did not affect the pharmacokinetics of venlafaxine and ODV. The clinical significance of this finding is unknown. It is important to continue taking this medication as prescribed even if you feel well. To help you remember, take it at the same times each day. Do not stop taking this medication without consulting your doctor. In some patients, additional was required. Boyd MA, Siangphoe U, Ruxrungtham K, et al. "The use of pharmacokinetically guided indinavir dose reductions in the management of indinavir-associated renal toxicity. Your pharmacist can provide more information about alosetron. Estazolam: CYP3A4 Inhibitors Strong may increase the serum concentration of Estazolam. CI: 50%, 86% lower than that observed 6 weeks postpartum. Six of these 11 55% patients had mean indinavir plasma concentrations 8 hours post-dose C min below assay threshold of reliable quantification. Midazolam: Protease Inhibitors may increase the serum concentration of Midazolam. Management: Oral midazolam contraindicated with all protease inhibitors. IV midazolam contraindicated with fosamprenavir and nelfinavir; other protease inhibitors recommend caution, close monitoring, and consideration of lower IV midazolam doses with concurrent use. where to purchase atopex otc
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Other medications can affect the removal of from your body, which may affect how indinavir works. DOCEtaxel: CYP3A4 Inhibitors Strong may increase the serum concentration of DOCEtaxel. Management: Avoid the concomitant use of docetaxel and strong CYP3A4 inhibitors when possible. If combined use is unavoidable, consider a 50% docetaxel dose reduction and monitor for increased docetaxel toxicities. Contraindicated if sildenafil being used for pulmonary arterial hypertension. Domperidone: CYP3A4 Inhibitors Strong may increase the serum concentration of Domperidone. Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. St. John's wort may decrease the amount of the HIV medicine in your body. The HIV medicine may not work against your HIV infection. F; protect from moisture. Dispense in original container desiccant should remain in the bottle.
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Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Crixivan, talk to your doctor about possible drug interactions and side effects. If you take any of these medicines together with Crixivan, you may be at increased risk of side effects such as low blood pressure, visual changes, and penile erection lasting more than 4 hours, which have been associated with sildenafil, tadalafil, and vardenafil. If an erection lasts longer than 4 hours, you should seek immediate medical assistance to avoid permanent damage to your penis. Your doctor can explain these symptoms to you. asato.info sinequan
Digestive System: liver function abnormalities; hepatitis including reports of hepatic failure see ; pancreatitis; jaundice; abdominal distention; dyspepsia. Imatinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Imatinib. Buprenorphine: CYP3A4 Inhibitors Strong may increase the serum concentration of Buprenorphine.
Take indinavir exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking indinavir without checking first with your doctor. Viracept nelfinavir mesylate US prescribing information. Lui A, Karter D, Turett G "Another case of breast hypertrophy in a patient treated with indinavir. IC 95. In general, higher levels of resistance were associated with the co-expression of greater numbers of substitutions, although their individual effects varied and were not additive. At least 3 amino acid substitutions must be present for phenotypic resistance to indinavir to reach measurable levels.
Moderate. These medicines may cause some risk when taken together. Who should not take ONGLYZA? AIDS. However, current scientific information indicates that smoking or inhaling marijuna might not be safe. Talk with your healthcare provider before using this product. Etoposide Phosphate: Atovaquone may increase the serum concentration of Etoposide Phosphate. Management: Consider separating the administration of atovaquone and etoposide by at least 1 to 2 days. It is critical to drink plenty of fluids while taking Crixivan. Adults should drink at least six 8-ounce glasses of liquids preferably water throughout the day, every day. Your health care provider will give you further instructions on the amount of fluid that you should drink. Crixivan can cause kidney stones. Having enough fluids in your body should help reduce the chances of forming a kidney stone. Call your doctor or other health care provider if you develop kidney pains middle to lower stomach or back pain or blood in the urine.